査読のある学術論文・著書・総説2010年以降
●Ziyu He, Takuhiro Uto, Shunsuke Tanigawa, Kozue Sakao, Kun Xie, Xuchi Pan, Shusong Wu, Masaharu Komatsu, De-Xing Hou.
Fisetin is a selective ATP-competitive MKK4 inhibitor to inhibit lipopolysaccharide-stimulated inflammation. BioFactors, in press.
●Shota Takumi, Masaru Tomioka, Yasunari Yunoki, Risa Eto, Yumiko Komatsu, Kazuhiro Shiozaki, Masaharu Komatsu.
Microcystin-LR-induced epithelial-mesenchymal transition-like cells acquire resistance to multi-toxins. Toxicon, 2023, Dec 30:238:107592.
●Toshiki Hyodo, Akinobu Honda, Satsuki Yamate, Yurina Kubo, Masaharu Komatsu and Kazuhiro Shiozaki
Elucidation of the mechanism of nuclear localization of Mexican tetra Neu4 via bipartite nuclear localization signal and less conserved regions. Biochimie, 212, 123-134, 2023.
●ShotaTakumi, Kairi Hashimoto, Masaru Tomioka, Mina Sato, Weijie He, Yumiko Komatsu, Shunji Aoki, Ryuji Ikeda, Kazuhiro Shiozaki, Tatsuhiko Furukawa, Masaharu Komatsu.
Acteoside from Conandron ramondioides Reduces Microcystin-LR Cytotoxicity by Inhibiting Intracellular Uptake Mediated by OATP1B3. Planta Medica., 88, 1-8, 2022.
●Daichi Sahashi, Yurina Kubo, Mika Ishii, Asami Ikeda, Chiharu Yamasaki, Masaharu Komatsu, Kazuhiro Shiozaki
Neu1 deficiency increases the susceptibility of zebrafish to Edwardsiella piscicida infection via lysosomal dysfunction. Gene, 836, 146667, 2022.
●Vo, KL., Tran, TN., Kubo, Y., Sahashi, D., Komatsu, M., Shiozaki, K. Enhancement of Edwardsiella piscicida infection, biofilm formation, and motility caused by N-acetylneuraminate lyase. Glycoconj. J. 2022. (in press)
●小松由美子，内匠正太，小松正治，村山恵美子，キビナゴの刺身に添える薬味の適性に関する考察. 鹿児島女子短期大学紀要，59, 1-4, 2022.
●Shota Takumi, Yumiko Komatsu, Yasuhito Domen, Tomoyuki Sumizawa, Kazuhiro Shiozaki, Manabu Ishikawa, Masaharu Komatsu, Seiichi Hayashi, and Shoji Yamada
Eel Serum Synergistically Enhances Growth of Fish Cell Line GAKS.
Mem. Fac. Fish. Kagoshima Univ.,70, 1-8, 2021.
●Asami Ikeda, Mayu Komamizu, Akito Hayashi, Chiharu Yamasaki, Kenji Okada, Momoko Kawabe, Masaharu Komatsu, Kazuhiro Shiozaki
Neu1 deficiency induces abnormal emotional behavior in zebrafish. Scientific Report, 11, article NO:13477, 2021.
●Oishi, K., Morise, M., Vo, KL., Tran, TN., Sahashi, D., Ueda-Wakamatsu, R., Nishimura, W., Komatsu, M., Shiozaki, K.
Host lactosylceramide enhances Edwardsiella tarda infection. Cellular Microbiology, 23, e13365, 2021.
●Honda, A., Hayasaka, O., Mio, K., Fujimura, K., Kotani, T., Komatsu, M., Shiozaki, K.
The involvement of Nile tilapia (Oreochromis niloticus) Neu4 sialidase in neural differentiation during early ontogenesis. Biochimie, 185, 105-116, 2021.
●Kawabe M, Hayashi A, Komatsu M, Inui A, Shiozaki K.
Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafish.
Neuropeptides. 2021 Jun;87:102136.
●Honda A, Chigwechokha PK, Takase R, Hayasaka O, Fujimura K, Kotani T, Komatsu M, Shiozaki K.
Novel Nile tilapia Neu1 sialidases: Molecular cloning and biochemical characterization of the sialidases Neu1a and Neu1b.
Gene. 2020 Jun 5;742:144538.
●Okada K, Takase R, Hamaoka Y, Honda A, Ikeda A, Hokazono Y, Maeda Y, Hayasaka O, Kotani T, Komatsu M, Shiozaki K.
Establishment and characterization of Neu1-knockout zebrafish and its abnormal clinical phenotypes.
Biochem J. 2020 Aug 14;477(15):2841-2857.
●Kazuki Oishi, Mina Miyazaki, Ryo Takase, Petros Kingstone Chigwechokha, Masaharu Komatsu and Kazuhiro Shiozaki
Regulation of triglyceride metabolism in medaka (Oryzias latipes) hepatocytes by Neu3a sialidase.
Fish Physiology and Biochemistry, 46, 563-574, 2020.
●林征一、小松正治、内匠正太
ニホンウナギ産卵回遊中の代謝に関する考察ービリルビン結合型U
生物の科学 遺伝, Vol.74(4), p353-367 (2020)
●Kazuhiro Shiozaki , Momoko Kawabe, Kiwako Karasuyama, Takayoshi Kurachi, Akito Hayashi, Koji Ataka, Haruki Iwai, Hinako Takeno, Oki Hayasaka, Tomonari Kotani, Masaharu Komatsu, Akio Inui
Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio)
Sci. Rep., 10, 5913, 2020.
●Linh Khanh Vo, Toshiharu Tsuzuki, Yuko Kamada-Futagami, Petros Kingstone Chigwechokha, Akinobu Honda, Kazuki Oishi, Masaharu Komatsu, Kazuhiro Shiozaki
Desialylation by Edwardsiella tarda is the initial step in the regulation of its invasiveness
Biochem. J., 476, 3183-3196, 2019.
●Honda, A., Chigwechokha, P., Kamada-Futagami, Y., Komatsu, M., Shiozaki, K.,
Unique nuclear localization of Nile tilapia (Oreochromis niloticus) Neu4 sialidase is regulated by nuclear transport receptor importin alpha/beta. Biochimie., 142, 94-104, 201, 2018．
●Aki Funahashi, Takao Itakura, Abeer A.I. Hassanin, Masaharu Komatsu, Seiichi Hayashi, Yoshio Kaminishi.
Ubiquitous distribution of fluorescent protein in muscles of four species and two subspecies of eel (genus Anguilla).
Journal of Genetics, 96, 127-133, 2017.
● Shota Takumi, Tai Shimono, Satoshi Ikema, Yuki Hotta, Petros K. Chigwechokha, Kazuhiro Shiozaki, Yasumasa Sugiyama, Mitsuru Hashimoto, Tatsuhiko Furukawa, Masaharu Komatsu*
Overexpression of Carboxylesterase Contributes to the Attenuation of Cyanotoxin
Microcystin-LR Toxicity
Comparative Biochemistry and Phyisiology C, 194, 22-27, 2017.
●Sayaka Shinyoshi, Yuko Kamada, Koki Matsusaki, Petros Kingstone Chigwechokha, Supawan Tepparin, Kyosuke Araki, Masaharu Komatsu, and Kazuhiro Shiozaki
Naringenin suppresses Edwardsiella tarda infection in GAKS cells by NanA sialidase inhibition.
Fish and Shellfish Immunology, 61, 86-92, 2017.
●Kazuhiro Shiozaki, Minori Yoshikawa, Saori Kiguchiya, Asami Ikeda, Yuko Kamada, Petros Kingstone Chigwechokha and Masaharu Komatsu.
Matrix metalloproteinase-7 inhibitory activity of lipid extract from dwarfgulper shark (Centrophorus atromarginatus) through down-regulation of gene transcription.
Journal of Functional Foods, 30, 90-96, 2017.
●Sena Ryuzono, Ryo Takase, Yuko Kamada, Takanori Ikenaga, Petros Kingstone Chigwechokha, Masaharu Komatsu, Kazuhiro Shiozaki.
Suppression of Neu1 sialidase delays the absorption of yolk sac in medaka (Oryzias
latipes) accompanied with the accumulation of alpha 2-3 sialo-glycoproteins.
Biochmie, 135, 63-71, 2017.
●Ayana Yoshinaga, Natsuki Kajiya, Kazuki Oishi, Yuko Kamada, Asami Ikeda, Petros Kingstone Chigwechokha, Toshiro Kibe, Michiko Kishida, Shosei Kishida, Masaharu Komatsu, Kazuhiro Shiozaki.
NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.
European Journal of Pharmacology, 782, 21-29, 2016.
●F Moinuddin, Yoshinari Shinsato, Masaharu Komatsu, Ryoichi Mitsuo, Kentaro Minami, Masatatsu Yamamoto, Kohichi Kawahara, Hirofumi Hirano, Kazunori Arita, Tatsuhiko Furukawa.
ATP7B expression confers multidrug resistance through drug sequestration. Oncotarget, 7, 22779-22790, 2016.
●Shiozaki, K., Harasaki, Y., Fukuda, M., Yoshinaga, A., Ryuzono, S., Chigwechokha, P., Komatsu M., Miyagi, T.
Positive regulation of myoblast differentiation by medaka Neu3b sialidase through ganglioside desialylation.
Biochimie,123, 65-72, 2016.
●Aki Funahashi, Masaharu Komatsu*, Tatsuhiko Furukawa, Yuki Yoshizono, Hikari Yoshizono, Yasuhiro Orikawa, Shota Takumi, Kazuhiro Shiozaki, Seiichi Hayashi, Yoshio Kaminishi, Takao Itakura.
Eel green fluorescent protein is associated with resistance to oxidative stress. Comparative Biochemistry and Physiology- C, 181-182, 35-39, 2016.
●Ryuzono, S., Takase, R., Oishi, K., Ikeda, A., Chigwechokha, P., Funahashi, A., Komatsu, M., Miyagi, T., Shiozaki, K.
Lysosomal localization of Japanese medaka (Oryzias latipes) Neu1 sialidase and its highly conserved enzymatic profiles with human.
Gene, 575, 513-523, 2016.
●小松正治
食の安全における安全な水.
鹿児島の食環境と健康食材, 南方新社., pp.193-205, 2016.
●Chigwechokha, P., Tabata, M., Shinyoshi, S., Oishi, K., Araki, K., Komatsu, M., Itakura, T., Shiozaki, K.
Recombinant sialidase NanA (rNanA) cleaves alpha 2-3-linked sialic acid of host cell surface N-linked glycoprotein to promote Edwardsiella tarda infection.
Fish Shellfish Immunol. 47, 34-45, 2015.
● Satoshi Ikema, Shota Takumi,Yuta Maeda, Takashi Kurimoto, Shinya Bohda, Petros Kingstone Chigwechokha, Yasumasa Sugiyama, Kazuhiro Shiozaki, Tatsuhiko Furukawa, Masaharu Komatsu*
Okadaic acid is taken-up into the cells mediated by human hepatocytes transporter OATP1B3.
Food and Chemical Toxicology, 83, 229-236, 2015.
●Ikeda, A., Ichino, H., Kiguchiya, S., Chigwechokha, P., Komatsu, M., Shiozaki, K.
Evaluation and identification of potent angiotensin-I converting enzyme inhibitory peptide derived from dwarf gulper shark (Centrophorus atromarginatus).
J. Food Process Pres. 39, 107-115, 2015.
●Shota Takumi, Satoshi Ikema, Tamami Hanyu, Yusuke Shima, Takashi Kurimoto, Kazuhiro Shiozaki, Yasumasa Sugiyama, Ho-Dong Park, Seiichi Ando, Tatsuhiko Furukawa, and Masaharu Komatsu*
Naringin attenuates the cytotoxicty of hepatotoxin microcystin-LR by the curious mechanisms to OATP1B1- and OATP1B3-expressing cells.
Environmental Toxicology and Pharmacology, 39, 974-981, 2015.
●Hiroyuki Takano, Shota Takumi, Satoshi Ikema, Nozomi Mizoue, Yuki Hotta, Kazuhiro Shiozaki, Yasumasa Sugiyama, Tatsuhiko Furukawa, and Masaharu Komatsu*
Microcystin-LR Induces Anoikis Resistance to the Hepatocyte Uptake Transporter OATP1B3-expressing Cell Lines.
Toxicology, 326, 53-61, 2014.
●Chigwechokha, P., Komatsu, M., Itakura, T., Shiozaki, K.
Nile Tilapia Neu3 sialidases: molecular cloning, functional characterization and expression in Oreochromis niloticus.
Gene, 552, 155-164, 2014.
●Liqiang Xie, Tamami Hanyu, Noriko Futatsugi, Masaharu Komatsu, Alan D. Steinman, Ho-Dong Park.
Inhibitory effect of naringin on microcystin-LR uptake in the freshwater snail Sinotaia histrica.
Environmental Toxicology and Pharmacology, 38, 430-437, 2014.
●Shiozaki, K., Ryuzono, S., Matushita, N., Ikeda, A., Takeshita, K., Chigwechokha, P., Komatsu, M., Miyagi, T.
Molecular cloning and biochemical characterization of medaka (Oryzias latipes) lysosomal neu4 sialidase.
J. Fish Physiol Biochem. 40, 1461-1472, 2014.
●Masaharu Komatsu*, Naoki Ichiyama, Takashi Kurimoto, Shota Takumi, Kazuhiro Shiozaki, Yasumasa Sugiyama, Tatsuhiko Furukawa, Seiichi Ando, Saki Itonori, and Hiroaki Saito.
Ceramide Aminoethylphosphonate from Jumbo flying squid Dosidicus gigas attenuates the toxicity of cyanotoxin microcystin-LR.
Fisheries Science, 79, 313-320, 2013.
●Kazuhiro Shiozaki, Kazuki Takeshtia, Mako Ikeda, Asami Ikeda, Yusuke Harasaki, Masaharu Komatsu, Shoji Yamada, Kazunori Yamaguchi and Taeko Miyagi.
Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes).
Biochimie, 95, 280-289, 2013.
●Yang Li, Wei Hongyi, Masaharu Komatsu, Kenichi Ishibashi, Tatsuo Ito, Takeshi Yoshikawa, and Hiroto Maeda.
Isolation and characterization of bacterial isolates algicidal against a harmful bloom-forming cyanobacterium Microsystis aeruginosa.
Biocontrol Science, 17, 107-114, 2012.
●Toyohiro Kato, Hiroaki Kawaguchi, Noriaki Miyoshi, Kohji Aoyama, Masaharu Komatsu, Masahisa Horiuchi, Hiroki Yoshida, Toru Takeuchi.
Effect of habitual exercise on renal carcinogenesis by ferric nitrilotriacetate.
Environmental Health and Preventive Medicine, 16, 232-238, 2011.
●Malay Choudhury, Takahiro Oku, Shoji Yamada, Masaharu Komatsu, Keita Kudoh, Takao Itakura, Seiichi Ando.
Isolation and characterization of some novel genes of apolipoprotein A-I family in Japanese eel, Anguilla japonica.
Central European Journal of Biology, 6, 545-557, 2011.
●Emiko Miyahara, Makiko Nishie, Shota Takumi, Hiroaki Miyanohara, Jun-ichiro Nishi, Kiyotaka Yoshiie, Hiroshi Oda, Minoru Takeuchi, Masaharu Komatsu, Kohji Aoyama, Masahisa Horiuchi, Toru Takeuchi.
Environmental mutagens may be implicated in emergence 1 of drug-resistant microbesa.
FEMS Microbiology Letters, 317, 109-116, 2011.
●Miyabi Hirashima, Kazuomi Tsuda, Toshiyuki Hamada, Hiroaki Okamura, Tatsuhiko Furukawa, Shin-ichi Akiyama, Yusuke Tajitsu, Ryuji Ikeda, Masaharu Komatsu, Matsumi Doe, Yoshiki Morimoto, Motoo Shiro, Rob W.M. van Soest, Kaoru Takemura and Tetsuo Iwagawa.
Cytotoxic Isomalabaricane Derivatives and a Monocytclic Triterpene Glycoside from the Sponge Rhabdastrella globostellata.
Journal of Natural Products, 73, 1512-1518, 2010.
●Shota Takumi, Masaharu Komatsu*, Tatsuhiko Furukawa, Ryuji Ikeda, Tomoyuki Sumizawa, Hitomi Akenaga, Yuta Maeda, Kohji Aoyama, Koji Arizono, Seiichi Ando,and Toru Takeuchi.
p53 plays an important role in cell fate determination after exposure to microcystin-LR.
Environmental Health Perspectives, 118, 1292-1298, 2010.
●Masaharu Komatsu*, Seiichi Ando, Seiichi Hayashi, Tatsuhiko Furukawa, Shota Takumi, Kohji Aoyama, and Toru Takeuchi.
A case study of intact vitellogenin isolated from the plasma of wild silver Japanese eel (Anguilla japonica).In Jackson E. Rathbond ed.
Handbook of Lipoprotein Research. Nova Science Publishers, Inc. pp. 195-205 , 2010.
2000年 ～ 2009年
●Kimiko Izumo, Masahisa Horiuchi, Masaharu Komatsu, Kohji Aoyama, Bandow K, Tetsuya Matsuguchi, Minoru Takeuchi, Toru Takeuchi.
Dehydroepiandrosterone increased oxidative stress in a human cell line during differentiation.
Free Radical Research, 43, 922-931, 2009.
●Malay Choudhury, Shoji Yamada, Masaharu Komatsu, Hideki Kishimura, and Seiichi Ando.
Homologue of mammalian apolipoprotein A-II in nonmammalian vertebrates.
Acta Biochimica et Biophysica Sinica, 41, 370-378, 2009.
●Takahiro Oku, Akira Sugawara, Malay Choudhury, Masaharu Komatsu, Shoji Yamada, and Seiichi Ando.
Lipid and fatty acid compositions differentiate between wild and cultured Japanese eel (Anguilla japonica).
Food Chemistry, 115, 436-440, 2009.
●Ryuji Ikeda, Yusuke Tajitsu, Ken-ichi Iwashita, Xiao-Fang Che, Kenichi Yoshida, Mina Ushiyama, Tatsuhiko Furukawa, Masaharu Komatsu, Tatsuya Yamaguchi, Yoshihiko Shibayama, Masatatsu Yamamoto, Hong-Ye Zhao, Junko Arima, Yasuo Takeda, Shin-ichi Akiyama, and Katsushi Yamada.
Thymidine Phosphorylase Inhibits the Expression of Proapoptic Protein BNIP3.
Biochemical and Biophysical Research Communications, 370, 220-224, 2008.
●Shota Takumi, Masaharu Komatsu, Kohji Aoyama, Kunimoto Watanabe, and Toru Takeuchi.
Oxygen induces mutation in a strict anaerobe, Prevotella melaninogenica.
Free Radical Biology and Medicine, 44, 1857-1862, 2008.
●Tatsuhiko Furukawa, Masaharu Komatsu, Ryuji Ikeda, Kazutake. Tsujikawa, and Shin-ichi Akiyama.
Copper transport systems are involved in multidrug resistance and drug transport.
Current Medicinal Chemistry, 15, 3268-3278, 2008.
●Qingqing Nong, Masaharu Komatsu, Kimiko Izumo, Hiroko P. Indo, Baohui Xu, Kohji Aoyama, Hideyuki J. Majima, Masahisa Horiuchi, Kanehisa Morimoto and Toru Takeuchi.
Involvement of reactive oxygen species in microcystin-LR-induced cytogenotoxicity.
Free Radical Research, 41, 1326-1337, 2007.
●Satsuki Owatari, Satoshi Akune, Masaharu Komatsu, Ryuji Ikeda, Stephen D. Firth, Xiao-Fang Che, Masatatsu Yamamoto, Kazutake Tsujikawa, Masaki Kitazono, Takashi Ishizuka, Toru Takeuchi, Takashi Aikou, Julian F.B. Mercer, Shin-ichi Akiyama and Tatsuhiko Furukawa.
Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer.
Cancer Research, 67, 4860-4868, 2007.
●Masaharu Komatsu*,Tatsuhiko Furukawa, Ryuji Ikeda, Shota Takumi, Qingqing Nong, Kohji Aoyama, Shin-ichi Akiyama, Dietrich Keppler and Toru Takeuchi.
Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3.
Toxicological Sciences, 97, 407-416, 2007.
●Masaharu Komatsu*, Seiichi Ando, Shota Takumi, Tatsuhiko Furukawa, Yumiko Komatsu, Kohji Aoyama, and Toru Takeuchi.
Development of a simple screening system for phytoecdysteroids in the environmental pollutants using mammalian cell line.
Current Topics in Pharmacology, 9, 81-89, 2005.
●Koji Nakatani, Masaharu Komatsu, Toyohiro Kato, Takao Yamanaka, Hiroaki Takekura, Akira Wagatsuma, Kohji Aoyama, Baohui Xu, Takeshi Hirano, Hiroshi Kasai, Seiichi Ando, and Toru Takeuchi.
Habitual exercise induced resistance against oxidative stress.
Free Radical Research, 39, 905-911, 2005.
●Katrin Letschert, Masaharu Komatsu, Johanna Hummel-Eisenbeiß, and Dietrich Keppler.
Vectorial Transport of the Peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2.
Journal of Pharmacology and Experimental Therapeutics, 313, 549-556, 2005
●Minyi Shi, Baohui Xu, Kazuko Azakami, Tomohiro Morikawa, Kunitomo Watanabe, Kanehisa Morimoto, Masaharu Komatsu, Kohji Aoyama, and Toru Takeuchi.
Dual role of vitamin C in an oxygen-sensitive system: Discrepancy between DNA damage and cell death.
Free Radical Research, 39, 213-220, 2005.
●Minyi Shi, Haruko Takeshita, Masaharu Komatsu, Baohui Xu, Kohji Aoyama, and Toru Takeuchi.
Generation of 8-hydroxydeoxyguanosine from DNA with rat liver homogenates.
Cancer Science, 96, 13-18, 2005.
●Masaharu Komatsu*, Tatsuhiko Furukawa, Masayuki Nakagawa, Kohji Aoyama, Toru Takeuchi, and Shin-ichi Akiyama.
Cisplatin resistance conferred by human copper transporter ATP7B.
Current Topics in Biotechnology, 1, 109-115, 2004.
●Misako Haraguchi, Hiroaki Tsujimoto, Masakazu Fukushima, Itsuro Higuchi, Hideto Kuribayashi, Hideo Utsumi, Atsuo Nakayama, Yoshio Hashizume, Junko Hirato, Hiroki Yoshida, Hiromitsu Hara, Shinjiro Hamano, Hiroaki Kawaguchi, Tatsuhiko Furukawa, Kohei Miyazono, Fuyuki Ishikawa, Hideo Toyoshima, Tadashi Kaname, Masaharu Komatsu, Zhe-Sheng Chen, Takenari Gotanda, Tokushi Tachiwada, Tomoyuki Sumizawa, Kazutaka Miyadera, Mitsuhiro Osame, Hiroki Yoshida, Tetsuo Noda, Yuji Yamada, and Shin-ichi Akiyama.
Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.
Molecular and Cellular Biology, 22, 5212 – 5221, 2002.
●Ryuji Ikeda, Tatsuhiko Furukawa, Masaki Kitazono, Kenji Ishitsuka, Hiroshi Okumura, Ayako Tani, Tomoyuki Sumizawa, Misako Haraguchi, Masaharu Komatsu, Hiroshi Uchimiya, Xiao-Qin Ren, Toshiro Motoya, Katsushi Yamada, and Shin-ichi Akiyama.
Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose.
Biochemical and Biophysical Research Communications,291, 806-812, 2002.
●(The first three authors contributed equally to this work) Zhe-sheng Chen, Shunji Aoki, Masaharu Komatsu, Kazumitsu Ueda, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Hiroshi Okumura, Xiao-Qin Ren, Martin G. Belinsky, Kun Lee, Gary D. Kruh, Motomasa Kobayashi, and Shin-ichi Akiyama.
Reversal of drug resistance mediated by multidrug resistance protein (MRP)1 by dual effects of Agosterol A on MRP1 function.
International Journal of Cancer, 93, 107-113, 2001.
●Masaharu Komatsu, Tomoyuki Sumizawa, Masato Mutoh, Zhe-Sheng Chen, Kunihiko Terada, Tatsuhiko Furukawa, Xiao-Li Yang, Huui Gao, Naoyuki Miura, Toshihiro Sugiyama, and Shin-ichi Akiyama.
Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.
Cancer Research, 60, 1312-1316, 2000.
●Hiroshi Okumura, Zhe-Sheng Chen, Magoichi Sakou, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Masaharu Komatsu, Ryuji Ikeda, Hikokazu Suzuki, Kosaku Hirota, Takashi Aikou, and Shin-ichi Akiyama.
Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB Cells by 5-O-Benzoylated Taxinin K.
Molecular Pharmacology, 58, 1563-1569, 2000.
●Xiao-Qin Ren, Tatsuhiko Furukawa, Zhe-Sheng Chen, Hiroshi Okumura, Shunji Aoki, Tomoyuki Sumizawa, Ayako Tani, Masaharu Komatsu, Xiao-Dong Mei, and Shin-ichi Akiyama.
Functional comparison between YCF1 and MRP1 expressed in Sf21 insect cells.
Biochemical and Biophysical Research Communications,270, 608-615, 2000.
●Seiichi Hayashi, Djibril Njiaye, Masaharu Komatsu, and Fu-Gong Yu.
Regulation of the synthesis and secretion of the lipoprotein by cultured eel (Anguilla japonica) hepatocytes.
Trends in Comparative Biochemistry and Physiology, 7, 123-130, 2000.
1999年以前
●Zhe-sheng Chen, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Kenji Ono, Ayako Tani, Masaharu Komatsu, and Shin-ichi Akiyama.
An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells.
Cancer Letters, 138, 13-22, 1999.
●Masaharu Komatsu* and Seiichi Hayashi.
Optimal conditions for estradiol-17β induced vitellogenin synthesis by cultured hepatocytes of eel, Anguilla japonica.
Fisheries Science, 64, 658 - 659, 1998.
●Masaharu Komatsu* and Seiichi Ando.
A very-high-density lipoprotein with clotting ability from hemolymph of sand crayfish, Ibacus ciliates.
Bioscience and Biotechnology and Biochemistry,62, 459 - 463, 1998.
●Seiichi Hayashi and Masaharu Komatsu.
Primary culture of eel hepatocytes - Synthesis and secretion of lipoprotein. In: Cell Tissue Culture: Laboratory Procedures. (A. Doyle, J.B. Griffiths and D.G. Newell eds.) ECACC, Centre for Applied Microbiology and Research, John Wiley and Sons LTD, Baffins Lane, Chichester, England, 23A:2.1-2.10, 1998.
●安藤清一, 小松正治
甲殻類血リンパリポタンパク質の新たな機能；甲殻類の生体防御機構の一端を担うアポリポタンパク質.
化学と生物. 36, 4-6, 1998.
●Masaharu Komatsu* and Seiichi Hayashi.
Pharmacological dose of estradiol-17β induces vitellogenin synthesis in cultured hepatocytes of immature eel Anguilla japonica.
Fisheries Science, 63, 989 - 994, 1997.
●Masaharu Komatsu, Wataru Matsumoto and Seiichi Hayashi.
Protease activity appeared after trypsin treatment of the purified vitellogenin from eel Anguilla japonica.
Comparative Biochemistry and Physiology, 113B, 561 - 571, 1996.
●Masaharu Komatsu and Seiichi Hayashi.
Proteinase activity of vitellogenin from crustacean sand crayfish Ibacus ciliatus as a latent form.
Fisheries Science, 60, 753 - 757, 1994.
●Masaharu Komatsu, Seiichi Ando and Shin-ichi Teshima.
Comparison of hemolymph lipoproteins from four species of Crustacea.
Journal of Experimental Zoology, 266,257 - 265, 1993.
●Masaharu Komatsu and Seiichi Ando.
Isolation of crustacean egg yolk lipoproteins by differential density gradient ultracentrifugation.
Comparative Biochemistry and Physiology, 103B, 363 -368, 1992.
●Masaharu Komatsu and Seiichi Ando.
A novel low-density lipoprotein with large amounts of phospholipid found in the egg yolk of Crustacea sand crayfish Ibacus ciliatus: Its function as vitellogenin-degrading proteinase.
Biochemical and Biophysical Research Communications, 186, 498 - 502, 1992.